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TC-G 1005
CAS No. 1415407-60-1
TC-G 1005( —— )
Catalog No. M22970 CAS No. 1415407-60-1
TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 58 | In Stock |
|
| 5MG | 95 | In Stock |
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| 10MG | 147 | In Stock |
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| 25MG | 309 | In Stock |
|
| 50MG | 447 | In Stock |
|
| 100MG | 668 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTC-G 1005
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NoteResearch use only, not for human use.
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Brief DescriptionTC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice.
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DescriptionTC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.
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In Vitro——
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In VivoAnimal Model:Male ICR mice Dosage:25, 50, 100 mg/kg Administration:A single p.o.Result:Increased the plasma active GLP-1 levels by 31, 96, and 282% at doses of 25, 50, and 100 mg/kg, respectively.
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Synonyms——
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PathwayGPCR/G Protein
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TargetGPCR19
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RecptorhTGR5
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Research Area——
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Indication——
Chemical Information
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CAS Number1415407-60-1
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Formula Weight399.49
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Molecular FormulaC25H25N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 33.33 mg/mL (83.43 mM)
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SMILESO=C(N1CCN(C2CC2)C3=C1C=CC=C3)C4=C(OC5=CC(C)=CC=C5C)C=CN=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Urso A , D'Ovidio F , Xu D , et al. Bile acids inhibit cholinergic constriction in proximal and peripheral airways from humans and rodents[J]. AJP Lung Cellular and Molecular Physiology, 2019, 318(2).
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TC-G 1005
TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice.
